1.Based on the results from the assessments in our case study, what do you think this clinical picture suggests?

MCI of unknown aetiology

MCI due to major depressive disorder

MCI due to AD

Mild AD dementia

Moderate AD dementia

2.Do you believe it is important to give a definitive aetiological diagnosis of AD using biomarkers?

Yes

No

Maybe

3.Why would you conduct Aβ confirmation specifically in an individual with MCI?

Increased certainty of diagnosis

Increased possibility to provide counselling / risk reduction strategies

Facilitate follow-up planning (i.e. regular follow up)

Patient desire

Other (i.e. clinical study)

4.Why would you not conduct Aβ confirmation in an individual with MCI?

Lack of standardised measurements and cut-off values

Lack of treatment possibility/availability

Data represent only group-level rather than individual-level basis

Psychological impact on individual/carer

Other (e.g. lack of guidelines, facilities, expertise)